Researchers are exploring an unconventional method of oxygen delivery known as “butt breathing.” Scientists from Cincinnati Children’s Hospital and the University of Osaka are investigating this approach to enhance oxygen levels when traditional lung function is compromised. The concept originated from Dr. Takanori Takebe, who became interested in alternative oxygen absorption methods after witnessing the challenges posed by invasive ventilators while treating his father for pneumonia.
Dr. Takebe drew inspiration from certain animals that can absorb oxygen through their skin or other bodily areas. He theorized that the human intestinal tract, which is rich in blood vessels, could also facilitate oxygen absorption. His hypothesis led to the development of a treatment that involves administering a liquid filled with oxygen through the rectum. Initial tests on mice and pigs demonstrated promising results, earning Dr. Takebe the 2024 Ig Nobel Prize, a satirical award recognizing unusual scientific achievements. During the award ceremony, he humorously accepted the honor while wearing a loach hat, stating, “Thank you so much for believing in the potential of the anus.”
Human Trials Begin
Following the success in animal studies, human trials have commenced in Japan. A group of twenty-seven men participated in the study, receiving non-oxygenated enemas to assess the maximum liquid volume they could tolerate within an hour. While a few participants reported mild stomach pain, most experienced only minor bloating and discomfort. The next phase will determine if oxygen can effectively reach the bloodstream through this method.
If clinical trials prove successful, butt breathing could serve as a short-term emergency solution. This would be particularly useful in situations such as ambulance transfers or bridging care during medical procedures, rather than as a replacement for traditional ventilators. Dr. Kevin Gibbs, a pulmonary critical care physician, acknowledged the innovative approach, stating, “It definitely raised my eyebrows. As someone who treats a lot of people who have low oxygen levels, I tend to think of myself as an above-the-waist doctor.”
While traditional methods of delivering oxygen often involve inserting tubes into a patient’s throat, which can pose risks of dangerously low oxygen levels, butt breathing could provide a critical boost in oxygen levels during these critical moments. Dr. Gibbs expressed enthusiasm about the potential benefits, remarking, “What I find exciting is if this drug works … maybe you can administer this, and then all of a sudden they have this real boost in oxygen for the time it takes you to safely put someone on life support – and that would be huge.”
As this research progresses, the medical community will be watching closely to see if this innovative method can enhance patient care in emergency situations, potentially revolutionizing how oxygen is delivered when time is of the essence.
