He Jiankui, the Chinese scientist who made headlines in 2018 for creating the world’s first gene-edited babies, is making plans to continue his controversial work. Following his release from prison in 2022, He is now focusing on a gene therapy for Duchenne muscular dystrophy and has expressed intentions to develop gene editing aimed at preventing Alzheimer’s disease.
Controversial Past and Ambitious Future
At a scientific conference in Hong Kong, He Jiankui announced the birth of three genetically modified girls, designed to be resistant to HIV. The implications of his work led to significant backlash, resulting in a three-year prison sentence and a government ban on reproductive gene editing in China. Now, He claims to be refocused on research that he believes could change the future of medicine.
Since his release, He has established an independent lab in Beijing and stated that he is currently working on a gene therapy targeting Duchenne muscular dystrophy. Although he has not published any results yet, he asserts that he has secured interest from a pharmaceutical company to advance this research. He aims to raise 50 million yuan (approximately $7 million) in funding to continue his work, with plans for clinical trials depending on regulatory approval.
New Directions in Gene Editing
He’s ambition extends beyond Duchenne muscular dystrophy. He is now looking at gene editing to prevent Alzheimer’s disease, specifically targeting the APP-A673T mutation, which is known to offer protection against the illness. He stated, “We want to introduce the mutation to the next generation, so they will have the same mutation as Icelandic people and be free of Alzheimer’s.” He is currently engaged in experiments involving human cell lines but has not yet begun working with embryos.
Despite facing challenges, including a ban on germline editing in China, He is exploring options to continue his work abroad. He has mentioned potential interest from South Africa, which recently updated its regulations regarding human genome editing. He indicated that discussions have begun with interested parties in the country.
He’s past has raised ethical questions around the implications of genetic modifications. He has publicly condemned attempts to enhance human intelligence through gene editing, labeling such efforts as akin to “Nazi eugenic experiments.” He differentiates his work as focused on disease prevention rather than enhancement.
As He Jiankui continues to navigate the complex landscape of genetic research, he remains a polarizing figure. He maintains an active presence on social media, referring to himself using terms like “Chinese Darwin” and “Oppenheimer in China,” while promoting transparency about his research.
His journey reflects the broader ethical and scientific debates surrounding gene editing, particularly regarding the balance between innovation and responsibility. As he aims to pave a new path in the field, the global scientific community watches closely, aware of the significant implications that his work may hold for future generations.
